Androgen receptor antagonist 12 [CAS 6605-17-0]
Androgen receptor antagonist 12 [CAS 6605-17-0]
SKU:QM-0094259
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Product Details
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Description
Androgen receptor antagonist 12 (Compound EF2) is an orally active Androgen receptor (AR) antagonist (IC50: 0.30 μM) . Androgen receptor antagonist 12 inhibits transcriptional activity of variant AR mutants and and the proliferation of AR-positive PCa cell lines. Androgen receptor antagonist 12 blocks AR nuclear translocation. Androgen receptor antagonist 12 inhibits tumor growth in a C4-2B xenograft mouse model. Androgen receptor antagonist 12 can be used for prostate cancer (PCa) research[1].
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CAS Number
[6605-17-0]
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Molecular Formula
C12H8F3N3O2
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Molecular Weight
283.21
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Smiles
FC(C1=CC(NC2=NC=C([N+]([O-])=O)C=C2)=CC=C1)(F)F
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Target
Androgen Receptor
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Shipping Conditions
Room temperature
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Androgen receptor antagonist 12 [CAS 6605-17-0]
Androgen receptor antagonist 12 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.