Androgen receptor antagonist 5 [CAS 2586195-28-8]
Androgen receptor antagonist 5 [CAS 2586195-28-8]
SKU:QM-0066921
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Product Details
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Description
Androgen receptor antagonist 5 (compound 42f) is a potent androgen receptor (AR) antagonist with an IC50 value of 6.17 μM. Androgen receptor antagonist 5 can effectively impair AR nuclear translocation, reducing the levels of nuclear AR, and disrupts AR-mediated gene regulation. Androgen receptor antagonist 5 has antiproliferative activity against LNCaP and exhibits antitumor activity in LNCaP xenograft tumor mice model. Androgen receptor antagonist 5 can be used for researching prostate cancer[1].
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CAS Number
[2586195-28-8]
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Molecular Formula
C21H15F4N5O3S
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Molecular Weight
493.43
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Smiles
CCOC(NC1=CC2=C(CC3C(N(C(N3C2)=S)C4=CC(C(F)(F)F)=C(N=C4)C#N)=O)C=C1F)=O
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Target
Androgen Receptor
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Androgen receptor antagonist 5 [CAS 2586195-28-8]
Androgen receptor antagonist 5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.