Antiproliferative agent-23 [CAS 3049213-47-7]
Antiproliferative agent-23 [CAS 3049213-47-7]
SKU:QM-0068691
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Product Details
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Description
Antiproliferative agent-23 is a microtubule-destabilizing agent (MDA) and efficiently disturbes the tubulin-microtubule system. Antiproliferative agent-23 induces apoptosis via a mitochondrion-dependent pathway by downregulating the Bcl-2 protein, upregulating Bax and Cyt c proteins, and activating the caspase cascade. Antiproliferative agent-23 initiates reactive oxygen species (ROS) -mediated endoplasmic reticulum stress in A549/CDDP cells (cisplatin resistant cancer cell line) via the PERK/ATF4/CHOP signaling pathway. Antiproliferative agent-23 has anti-tumor activity[1].
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CAS Number
[3049213-47-7]
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Molecular Formula
C23H28Cl3N3O6Pt
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Molecular Weight
743.93
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Smiles
O=C(C1=CC(OC)=C(C(OC)=C1)OC)/C=C/C2=CC=CC3=C2C=CN3CCC(O[Pt](Cl)(Cl)(Cl)([NH3])[NH3])=O
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Target
Apoptosis; Microtubule/Tubulin
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Antiproliferative agent-23 [CAS 3049213-47-7]
Antiproliferative agent-23 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.