APJ receptor agonist 4 [CAS 2762567-70-2]
APJ receptor agonist 4 [CAS 2762567-70-2]
SKU:QM-0066162
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Product Details
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Description
APJ receptor agonist 4 is a potent and orally active agonist of apelin receptor (APJ) with EC50 and Ki of 0.06 nM and 0.07 nM respectively. APJ receptor agonist 4 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 4 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 4 leads to improved cardiac function and can be used for researching the HF disease[1].
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CAS Number
[2762567-70-2]
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Molecular Formula
C28H28ClFN6O3
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Molecular Weight
551.01
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Smiles
O=C1C(C(N2CC[C@@H](C3=C(F)C=C(Cl)C=N3)C2)=O)=C(O)N(C4=C(CC)C=CC=C4CC)C(C5=NN(C)C=C5)=N1
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Target
Apelin Receptor (APJ)
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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APJ receptor agonist 4 [CAS 2762567-70-2]
APJ receptor agonist 4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.