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AR antagonist 12 [CAS 2902679-42-7]
AR antagonist 12 [CAS 2902679-42-7]
SKU:QM-0011631
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Product Details
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Description
AR antagonist 12 (compound 20i) is an orally active androgen receptor antagonist wiith IC50 values of 119.3 μM and 98.2 μM for wt-AR and AR-F877L, respectively. AR antagonist 12 induces a dose-dependent and time-dependent reduction in AR, AR-V7, and PSA protein levels. AR antagonist 1 shows anticancer activuty and can be used for the study of Enzalutamide -resistant Prostate cancer[1].
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CAS Number
[2902679-42-7]
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Molecular Formula
C24H23F3N6O2
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Molecular Weight
484.47
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Smiles
O=C(NC1=CN=C(C(C(F)(F)F)=C1)C#N)[C@@](O)(CN2CC3CCC(N3C4=CC=C(C=C4)C#N)C2)C
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Target
Androgen Receptor
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Shipping Conditions
Room temperature
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AR antagonist 12 [CAS 2902679-42-7]
AR antagonist 12 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.