AR antagonist 15 [CAS 1790308-86-9]
AR antagonist 15 [CAS 1790308-86-9]
SKU:QM-0011977
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Product Details
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Description
AR antagonist 15 is an orally active androgen receptor (AR) antagonist with the IC50 of 97 nM for ART787A. AR antagonist 15 disrupts AR nuclear translocation, hinders AR homodimerization, and suppresses transcription of AR-regulated genes by competitive binding to the ligand binding pocket. AR antagonist 15 can significantly lower the prostate-specific antigen (PSA) level. AR antagonist 15 induces apoptosis by reducing the expression of apoptosis pathway related proteins. AR antagonist 15 can be used for the research of prostate cancer[1].
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CAS Number
[1790308-86-9]
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Molecular Formula
C18H22N2O3S
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Molecular Weight
346.44
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Smiles
O=S(NC1=CC=C(C=C1)OCC2=CC=CC=C2)(N3CCCCC3)=O
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Target
Androgen Receptor; Apoptosis
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Shipping Conditions
Room temperature
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AR antagonist 15 [CAS 1790308-86-9]
AR antagonist 15 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.