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BKCa activator-1
BKCa activator-1
SKU:QM-0009704
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Product Details
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Description
BKCa activator-1 (Compound 51b) is the orally active activator for the calcium-activated potassium channel BKCa with an EC50 of 2.82 μM. BKCa activator-1 increases K+ efflux, leads to cell membrane hyperpolarization, thereby inhibiting smooth muscle contraction. BKCa activator-1 alleviates urinary incontinence in spontaneously hypertensive rat (SHR) model, exhibits antitussive effect in puinea pig cough model[1].
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Molecular Formula
C22H23F7N2O3
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Molecular Weight
496.42
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Smiles
OC1=C(C=CC(NCCCCCN2CCOCC2)=C1)OC3=C(C(F)=C(C(F)=C3F)C(F)(F)F)F
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Target
Potassium Channel
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Shipping Conditions
Room temperature
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BKCa activator-1
BKCa activator-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.