BRD4 Inhibitor-40 [CAS 2994635-04-8]
BRD4 Inhibitor-40 [CAS 2994635-04-8]
SKU:QM-0011181
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Product Details
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Description
BRD4 Inhibitor-40 (Compound 23) is the inhibitor for BRD that inhibits BRD4-BD1, BRD4-BD2, BRD2-BD1 and BRD2-BD2 with IC50s of 16.1, 142.18, 29.35 and 302.35 nM, respectively. BRD4 Inhibitor-40 modulates the expression of c-Myc and p21, arrests cell cycle at G1 phase, inhibits Pkd1-null (PN) renal cystic epithelial cells, and blocks the renal cysts formation in Madin-Darby canine kidney and embryonic kidney vesicle models. BRD4 Inhibitor-40 exhibits renal cysts inhibitory activity in mouse models[1].
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CAS Number
[2994635-04-8]
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Molecular Formula
C27H32N8O
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Molecular Weight
484.6
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Smiles
CC(N1C2=CC(NC3=NC(CC)=CC(NC4=NN(C)C5=CC=CC=C45)=N3)=CC=C2N(C([C@H]1C)=O)C)C
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Target
C-Myc; Epigenetic Reader Domain
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Isoform
BRD2; BRD4
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Shipping Conditions
Room temperature
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BRD4 Inhibitor-40 [CAS 2994635-04-8]
BRD4 Inhibitor-40 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.