C-MYC/BCL2 ligand 1 (iodide)
C-MYC/BCL2 ligand 1 (iodide)
SKU:QM-0011989
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Product Details
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Description
C-MYC/BCL2 ligand 1 iodide is a dual-targeting c-MYC/Bcl-2 G4 ligand with Kd values of 0.90 μM (c-MYC G4) and 0.56 μM (Bcl-2 G4) . c-MYC/BCL2 ligand 1 iodide inhibits c-MYC and Bcl-2 gene transcription by binding to G4-forming sequences and downregulates their protein expression. c-MYC/BCL2 ligand 1 iodide inhibits suppresses migration, induces caspase-dependent apoptosis, and triggers cell cycle G1 arrest in MCF-7 cells. c-MYC/BCL2 ligand 1 iodide significantly suppresses tumor growth in a 4T1 syngeneic model with no observable toxicity. c-MYC/BCL2 ligand 1 iodide can be used for the research of breast cancer[1].
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Molecular Formula
C36H45IN2O3S
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Molecular Weight
712.72
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Smiles
CC[N+]1=C(/C=C/C2=CC=C(OCCNS(C3=C(C(C)C)C=C(C(C)C)C=C3C(C)C)(=O)=O)C=C2)C=CC4=CC=CC=C41.[I-]
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Target
Apoptosis; Bcl-2 Family; Caspase; c-Myc
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Isoform
Bcl-2; Caspase 9
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Shipping Conditions
Room temperature
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C-MYC/BCL2 ligand 1 (iodide)
C-MYC/BCL2 ligand 1 (iodide) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.