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C5aR1 antagonist 2 [CAS 2365161-92-6]
C5aR1 antagonist 2 [CAS 2365161-92-6]
SKU:QM-0118832
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Product Details
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Description
C5aR1 antagonist 2 (Compound 6a) is an orally active C5a receptor 1 (C5aR1) antagonist that shows efficacy in inhibiting the C5a-induced neutrophil count increase. C5aR1 antagonist 2 is potent in the DISCO and migration assays, with IC50 values of 21 and 3 nM, respectively. C5aR1 antagonist 2 can be used for the research of acute and chronic inflammatory diseases[1].
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CAS Number
[2365161-92-6]
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Molecular Formula
C29H30F3N3O2
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Molecular Weight
509.56
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Smiles
O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=C(N1C4CCN(CC4)C5=C(C)C=CC=C5C)C=CC=C3OC
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Target
Complement System
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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C5aR1 antagonist 2 [CAS 2365161-92-6]
C5aR1 antagonist 2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.