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CCR4 antagonist 2 [CAS 2206788-99-8]
CCR4 antagonist 2 [CAS 2206788-99-8]
SKU:QM-0060739
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Product Details
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Description
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively[1].
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CAS Number
[2206788-99-8]
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Molecular Formula
C26H28Cl2N6O
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Molecular Weight
511.45
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Smiles
ClC(C=C(Cl)C=C1)=C1[C@@H](C)N2N=C(C#N)C3=C2N=C(C4=CC[C@H](N5[C@H](CO)CCC5)[C@H](C)C4)C=N3
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Target
CCR
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Isoform
CCR4
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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CCR4 antagonist 2 [CAS 2206788-99-8]
CCR4 antagonist 2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.