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CDK12 ligand-3 [CAS 3093763-27-7]
CDK12 ligand-3 [CAS 3093763-27-7]
SKU:QM-0014795
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Product Details
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Description
CDK12 ligand-3 is a molecular glucose degrading agent that targets the CDK12 protein (DC50 = 35 nM) . CDK12 ligand-3 degrades CDK12, CDK13 and their regulatory subunit Cyclin K in a concentration dependent manner, and inhibits RNA polymerase II CTD (Ser2) phosphorylation. CDK12 ligand-3 exhibits potent anti proliferative activity against Jurkat cells. CDK12 ligand-3 can be used for research on cancers such as leukemia[1].
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CAS Number
[3093763-27-7]
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Molecular Formula
C25H28ClN5O3S
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Molecular Weight
514.04
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Smiles
ClC1=CN=C(N[C@H]2CN(CCC2)C(C3=CC=CC=C3)=O)N=C1NC4=CC=CC=C4S(=O)(C(C)C)=O
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Target
CDK; Molecular Glues
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Shipping Conditions
Room temperature
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CDK12 ligand-3 [CAS 3093763-27-7]
CDK12 ligand-3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.