(E/Z) -Necrosulfonamide [CAS 432531-71-0]
(E/Z) -Necrosulfonamide [CAS 432531-71-0]
SKU:QM-0079461-01
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Product Details
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Description
(E/Z) -Necrosulfonamide is a racemic compound of Necrosulfonamide. Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways.
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CAS Number
[432531-71-0]
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Molecular Formula
C18H15N5O6S2
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Molecular Weight
461.47
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Smiles
O=C(/C=C/C1=CC=C(S1)[N+]([O-])=O)NC2=CC=C(C=C2)S(=O)(NC3=NC=CN=C3OC)=O
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Target
Caspase; Heme Oxygenase (HO) ; Interleukin Related; Keap1-Nrf2; Mixed Lineage Kinase; Necroptosis; NO Synthase; NOD-like Receptor (NLR) ; Pyroptosis; TNF Receptor
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Purity
98.84
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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(E/Z) -Necrosulfonamide [CAS 432531-71-0]
(E/Z) -Necrosulfonamide is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.