EMT inhibitor-3 [CAS 2930726-89-7]
EMT inhibitor-3 [CAS 2930726-89-7]
SKU:QM-0009714
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Product Details
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Description
EMT inhibitor-3 (compound 11i) is a epithelial-mesenchymal transition (EMT) inhibitor. EMT inhibitor-3 inhibits neuroblastoma SK-N-SH cells with an IC50 of 2.5 μM. EMT inhibitor-3 inhibits SK-N-SH cell proliferation, migration, and invasion. EMT inhibitor-3 increases the Bax/Bcl-2 protein expression ratio, promotes Cytochrome C release from mitochondria, and activates caspases 9 and caspases 3, inducing mitochondria-mediated endogenous tumor cell Apoptosis. EMT inhibitor-3 is potential for cancer research[1].
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CAS Number
[2930726-89-7]
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Molecular Formula
C29H21F2N3O4Se
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Molecular Weight
592.45
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Smiles
O=C1C(C(N2N=C(C3=CC=C(F)C=C3)CC2C4=CC=C(F)C=C4)=O)=CC5=C(O1)C=C(OCCC[Se]C#N)C=C5
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Target
Apoptosis; Bcl-2 Family; Caspase; Cytochrome P450
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Isoform
Bax; Bcl-2; Caspase 3; Caspase 9
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Shipping Conditions
Room temperature
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EMT inhibitor-3 [CAS 2930726-89-7]
EMT inhibitor-3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.