EP300/CBP ligand 2
EP300/CBP ligand 2
SKU:QM-0085474
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Product Details
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Description
EP300/CBP ligand 2 (compound S19) is a ligand targeting the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). EP300/CBP ligand 2 can be used as a target protein ligand in the PROTAC structure, and can be coupled to the E3 ubiquitin ligase ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, EP300/CBP ligand 2 can be coupled with the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc to produce the PROTAC molecule dCE-2 (HY-161958).
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Molecular Formula
C20H18N6O
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Molecular Weight
358.4
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Smiles
NC1=CC(C2=NN(C)C=C2)=CC(C(NC3=CC=CC4=C3C=C(C)N=N4)=O)=C1
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Target
Epigenetic Reader Domain; Ligands for Target Protein for PROTAC
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Shipping Conditions
Room temperature
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EP300/CBP ligand 2
EP300/CBP ligand 2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.