EP4 receptor antagonist 7 [CAS 3035217-40-1]
EP4 receptor antagonist 7 [CAS 3035217-40-1]
SKU:QM-0009072-01
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Product Details
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Description
EP4 receptor antagonist 7 (Compound 14) is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 with an IC50 value of 1.1 nM. EP4 receptor antagonist 7 inhibits PGE2-induced β-arrestin recruitment in HEK293 cells with an IC50 value of 0.9 nM. EP4 receptor antagonist 7 decreases PGE2-induced expression of mRNA encoding IL-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C) motif ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase-1 (Arg1), in RAW 264.7 macrophages. EP4 receptor antagonist 7 combined with an anti-PD-1 antibody inhibits tumor growth and increases infiltration of CD8+ T cells into tumors in a CT26 murine colon cancer model[1].
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CAS Number
[3035217-40-1]
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Molecular Formula
C24H18F3N3O3
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Molecular Weight
453.41
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Smiles
O=C(C1=CC=C(CNC(C2=C3C=CC=CC3=NN2CC4=CC=C(C(F)(F)F)C=C4)=O)C=C1)O
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Target
Interleukin Related; Prostaglandin Receptor
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Shipping Conditions
Room temperature
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EP4 receptor antagonist 7 [CAS 3035217-40-1]
EP4 receptor antagonist 7 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.