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ER covalent antagonist-1 [CAS 2757498-74-9]
ER covalent antagonist-1 [CAS 2757498-74-9]
SKU:QM-0009266
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Product Details
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Description
ER covalent antagonist-1 (Compound 39D) is the antagonist for estrogen receptor α (ERα) . ER covalent antagonist-1 inhibits the proliferation of ERα-positive cell MCF-7 with an IC50 of 0.98 μM, arrests the cell cycle at G0/G1 phase, and induces apoptosis. ER covalent antagonist-1 exhibits antitumor efficacy in mouse model[1].
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CAS Number
[2757498-74-9]
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Molecular Formula
C33H32N2O5S
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Molecular Weight
568.68
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Smiles
O=C(C1=CC=CC=C1)C(SC2=CC(O)=CC=C23)=C3OC4=CC=C(C=C4)OC5CN(C5)C/C=C/C(N6CCCCC6)=O
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Target
Apoptosis; Estrogen Receptor/ERR
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Shipping Conditions
Room temperature
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ER covalent antagonist-1 [CAS 2757498-74-9]
ER covalent antagonist-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.