ERK1/2 inhibitor 10 [CAS 3056077-07-4]
ERK1/2 inhibitor 10 [CAS 3056077-07-4]
SKU:QM-0134810
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Product Details
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Description
ERK1/2 inhibitor 10 (Compound 36c) is a potent ERK1 and ERK2 inhibitor (IC50: 0.11 and 0.08 nM respectively) . ERK1/2 inhibitor 10 inhibits ERK1/2 and blocks the phosphorylation expression of their downstream substrates p90RSK and c-Myc. ERK1/2 inhibitor 10 induces cell apoptosis and incomplete autophagy-related cell death. ERK1/2 inhibitor 10 shows potent antitumor efficacy against triple-negative breast cancer and colorectal cancer models harboring BRAF and RAS mutations[1].
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CAS Number
[3056077-07-4]
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Molecular Formula
C23H20ClN5O2S
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Molecular Weight
465.96
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Smiles
O=C(C1=CC(C2=NC(NC3=CC=NC(C)=C3)=NC=C2Cl)=CS1)N[C@@H](C4=CC=CC=C4)CO
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Target
ERK
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Isoform
ERK1; ERK2
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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ERK1/2 inhibitor 10 [CAS 3056077-07-4]
ERK1/2 inhibitor 10 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.