ERK1/2 inhibitor 13 [CAS 3093367-23-5]
ERK1/2 inhibitor 13 [CAS 3093367-23-5]
SKU:QM-0011180
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Product Details
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Description
ERK1/2 inhibitor 13 (Compound 21y) is the orally active inhibitor for ERK that inhibits ERK1 and ERK2 with IC50 of 91.71 nM and 97.87 nM. ERK1/2 inhibitor 13 inhibits the proliferation of MCF-7, 4T1, MDA-MB-468, and HCC1970 (IC50 of 0.67, 2.76, 2.15 and 1.68 μM), inhibits the cancer cell migration, induces apoptosis and autophagy in MCF-7. ERK1/2 inhibitor 13 exhibits antitumor and anti-metastatic effect in 4T1 xenograft mouse model[1].
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CAS Number
[3093367-23-5]
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Molecular Formula
C36H29BrF6N4O
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Molecular Weight
727.54
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Smiles
FC(F)(C1=CC(NC(N[C@@H](CC2=CC=CC=C2)CN3C=[N+](CC4=CC=CC5=C4C=CC=C5)C6=C3C=CC=C6)=O)=CC(C(F)(F)F)=C1)F.[Br-]
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Target
Apoptosis; Autophagy; ERK
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Isoform
ERK1; ERK2
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Shipping Conditions
Room temperature
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ERK1/2 inhibitor 13 [CAS 3093367-23-5]
ERK1/2 inhibitor 13 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.