FKBP12 ligand-2 [CAS 3036243-81-6]
FKBP12 ligand-2 [CAS 3036243-81-6]
SKU:QM-0013960
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Product Details
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Description
FKBP12 ligand-2 (compound d) is a high affinity ligand targeting FKBP12. FKBP12 ligand-2 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-2 can be used for selective cancer research based on differences in intracellular presenter protein levels[1].
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CAS Number
[3036243-81-6]
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Molecular Formula
C24H25Cl2N3O4S
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Molecular Weight
522.44
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Smiles
O=C1[C@H]2N(S(C3=CC(Cl)=CC(Cl)=C3)(=O)=O)[C@@H]([C@@H](CN1CC4=NC=CC=C4)COCC#C)CCC2
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Target
FKBP
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Isoform
FKBP12
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Shipping Conditions
Room temperature
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FKBP12 ligand-2 [CAS 3036243-81-6]
FKBP12 ligand-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.