FKBP12 ligand-3 [CAS 3036374-26-9]
FKBP12 ligand-3 [CAS 3036374-26-9]
SKU:QM-0013961
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Product Details
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Description
FKBP12 ligand-3 (compound dj) is a high-affinity ligand targeting FKBP12. FKBP12 ligand-3 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-3 can be used for selective cancer research based on differences in intracellular presenter protein levels[1].
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CAS Number
[3036374-26-9]
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Molecular Formula
C25H27Cl2N3O4S
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Molecular Weight
536.47
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Smiles
O=C(N([C@@H](C)C1=NC=CC=C1)C[C@@H]2COCC#C)[C@@]3([H])N([C@]2([H])CCC3)S(C4=CC(Cl)=CC(Cl)=C4)(=O)=O
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Target
FKBP
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Isoform
FKBP12
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Shipping Conditions
Room temperature
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FKBP12 ligand-3 [CAS 3036374-26-9]
FKBP12 ligand-3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.