FOXJ1 agonist 1
FOXJ1 agonist 1
SKU:QM-0086362
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Product Details
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Description
FOXJ1 agonist 1 (compound 16c) is an orally effective small molecule that can effectively enhance the expression of FOXJ1. Foxj1-IN-1 acts on the mammalian airway system composed of multiciliated cells (MCC) to prevent the development and onset of chronic obstructive pulmonary disease (COPD) . Foxj1-IN-1 can induce the production of motile cilia in the respiratory system of zebrafish and mammals, and inhibit elastase-induced COPD mouse models. Foxj1-IN-1 has good liver microsomal stability, in vivo PK curve and AUC; it has no significant inhibition of CYP and hERG, and does not have significant cytotoxicity[1].
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Molecular Formula
C24H27N5O3
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Molecular Weight
433.5
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Smiles
CC(C)(N1N=CC(C2=CC(C3=NC4=CC=CC=C4O3)=C(NC(C)(C)C)N=C2)=C1)CC(O)=O
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Target
FOXO; NF-κB
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Shipping Conditions
Room temperature
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FOXJ1 agonist 1
FOXJ1 agonist 1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.