FPR2 agonist 5
FPR2 agonist 5
SKU:QM-0015019
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Product Details
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Description
FPR2 agonist 5 is a selective Formyl Peptide Receptor 2 (FPR2) agonist. FPR2 agonist 5 induces Ca2+ mobilization in FPR2-HL60 transfected cells with an EC50 of 1.2 μM and causes FPR2 desensitization with an IC50 of 0.32 μM. FPR2 agonist 5 exerts neuroprotective effects by mitigating LDH release, NO production, IL-1β, IL-6, IL-33, and IL-10 levels in LPS -induced mouse primary microglial cells. FPR2 agonist 5 can be used for the study of neuroinflammatory-related diseases[1].
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Molecular Formula
C26H20FN5O2
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Molecular Weight
453.47
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Smiles
N#CC1=CC=C(C[C@H](NC2=NN=C(C3=CC=C(F)C=C3)O2)C(N4CCC5=C4C=CC=C5)=O)C=C1
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Target
Calcium Channel; Formyl Peptide Receptor (FPR) ; Interleukin Related; NO Synthase
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Shipping Conditions
Room temperature
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FPR2 agonist 5
FPR2 agonist 5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.