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FXR antagonist 1 [CAS 2295804-68-9]

FXR antagonist 1 [CAS 2295804-68-9]

Size

QM-0150539-01

£865.26 GBP
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Product Details

  • Description

    FXR antagonist 1 (compound F6) is an orally active and selective intestinal FXR antagonist (IC50=2.1 μM) . FXR antagonist 1 selectively inhibits intestinal FXR signalling through antagonism of intestinal FXR and feedback activation of hepatic FXR to improve hepatic steatosis, inflammation and fibrosis in NASH (nonalcoholic steatohepatitis) models. FXR antagonist 1 can be used in NASH studies[1].

  • CAS Number

    [2295804-68-9]

  • Molecular Formula

    C36H59NO5

  • Molecular Weight

    585.86

  • Smiles

    OC(CNC([C@]12[C@@]([C@@H](CC2)C(C)C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)([C@@H](CC5)OC(CCC)=O)C)([H])CC4)C)([H])CC3)C)C)=O)=O

  • Target

    FXR

  • Purity

    98.01

  • Solubility

    DMSO : 100 mg/mL (ultrasonic)

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature
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Variant Variant total Quantity Price Variant total
5 mgQM-0150539-01
5 mgQM-0150539-01
£865.26/ea		 £0.00
£865.26/ea £0.00
10 mgQM-0150539-02
10 mgQM-0150539-02
£1,354.91/ea		 £0.00
£1,354.91/ea £0.00
25 mgQM-0150539-03
25 mgQM-0150539-03
£2,661.03/ea		 £0.00
£2,661.03/ea £0.00
50 mgQM-0150539-04
50 mgQM-0150539-04
£4,481.10/ea		 £0.00
£4,481.10/ea £0.00
100 mgQM-0150539-05
100 mgQM-0150539-05
£7,580.57/ea		 £0.00
£7,580.57/ea £0.00
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FXR antagonist 1 [CAS 2295804-68-9]

FXR antagonist 1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.