GCN2 activator-1 [CAS 315705-10-3]
GCN2 activator-1 [CAS 315705-10-3]
SKU:QM-0051551-01
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Product Details
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Description
GCN2 activator-1 (Compound 20) is a GCN2 activator. GCN2 activator-1 binds within the ATP-pocket of GCN2 and activates GCN2 in a GCN1-independent manner. GCN2 activator-1 activates Integrated Stress Response (ISR) in cells. GCN2 activator-1 inhibits PKR with an IC50 of 3.75 µM. GCN2 activator-1 can be used for research of pulmonary veno-occlusive disease (PVOD) [1].
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CAS Number
[315705-10-3]
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Molecular Formula
C11H10N6S2
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Molecular Weight
290.37
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Smiles
NC1=NC(C)=C(C2=CSC(NC3=NC=CC=N3)=N2)S1
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Target
Eukaryotic Initiation Factor (eIF) ; Pyruvate Kinase
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Isoform
EIF2
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Purity
99.69
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Solubility
DMSO : 4.55 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years (Powder)
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Shipping Conditions
Blue Ice
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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GCN2 activator-1 [CAS 315705-10-3]
GCN2 activator-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.