Glucagon receptor antagonist-7 [CAS 438618-32-7]
Glucagon receptor antagonist-7 [CAS 438618-32-7]
SKU:QM-0142291
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Product Details
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Description
Glucagon receptor antagonist-7 (Compound 1) is an antagonist for hGCGR, that inhibits the binding of 125I-labeled glucagon to the human glucagon receptor (hGCGR) with IC50 of 181 nM. Glucagon receptor antagonist-7 activates glucagon-stimulated adenylyl cyclase with a KDB of 81 nM in CHO cell. Glucagon receptor antagonist-7 inhibits glucagon-mediated glycogenolysis in human hepatocytes, and lowers blood glucose levels[1].
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CAS Number
[438618-32-7]
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Molecular Formula
C20H30N2OS
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Molecular Weight
346.53
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Smiles
CCC(CC)C(NC1=C(C#N)C(CCC(C(C)(C)CC)C2)=C2S1)=O
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Target
Adenylate Cyclase; GCGR
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H315-H319-H335
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Glucagon receptor antagonist-7 [CAS 438618-32-7]
Glucagon receptor antagonist-7 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.