Glucocerebrosidase-IN-2 [CAS 851185-20-1]
Glucocerebrosidase-IN-2 [CAS 851185-20-1]
SKU:QM-0072171-01
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Product Details
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Description
Glucocerebrosidase-IN-2 (compound 12) is a quinazoline analogue and an inhibitor of glucocerebrosidase (GC) . Glucocerebrosidase-IN-2 has the potential to improve GC translocation to lysosomes in Gaucher disease patient-derived cells (mostly carrying the N370S mutation) . Glucocerebrosidase-IN-2 inhibits the hydrolysis of 4-methylumbelliferone β-D-glucopyranoside (4MU) and fluorescent glycosylceramide (FlourGC) in N370S mutant tissues with an AC50 of 25.29 μM[1].
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CAS Number
[851185-20-1]
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Molecular Formula
C25H23N5O4S
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Molecular Weight
489.55
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Smiles
O=S(C1=CC=C2OCCOC2=C1)(N3CCN(C4=NC(C5=CN=CC=C5)=NC6=C4C=CC=C6)CC3)=O
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Target
Glycosidase
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H315-H319-H320
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Precautions
P264-P280-P302+P352-P305+P351+P338-P362
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Glucocerebrosidase-IN-2 [CAS 851185-20-1]
Glucocerebrosidase-IN-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.