Glucocorticoid receptor/NF-κB modulator-1
Glucocorticoid receptor/NF-κB modulator-1
SKU:QM-0134301
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Product Details
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Description
Glucocorticoid receptor/NF-κB modulator-1 (Compound 20) is a derivative of ocotillol. Glucocorticoid receptor/NF-κB modulator-1 suppresses the degradation of glucocorticoid receptor (GR) mRNA and GR protein, inhibits the activation of NF-κB signaling pathway. Glucocorticoid receptor/NF-κB modulator-1 downregulates levels of NO, interleukin-6 and tumor necrosis factor-alpha (TNF-α) . Glucocorticoid receptor/NF-κB modulator-1 ameliorates sepsis in mouse model[1].
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Molecular Formula
C39H62N2O6S
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Molecular Weight
686.98
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Smiles
[H][C@@]12[C@](CC[C@@H]2[C@]3(C)CC[C@@H](C(C)(O)C)O3)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C6=C(SC(NC(CCC(OC(C)(C)C)=O)=O)=N6)C[C@]5(C)[C@@]4([H])C[C@H]1O
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Target
Glucocorticoid Receptor; NF-κB
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Glucocorticoid receptor/NF-κB modulator-1
Glucocorticoid receptor/NF-κB modulator-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.