GSK-3β inhibitor 13 [CAS 2227316-74-5]
GSK-3β inhibitor 13 [CAS 2227316-74-5]
SKU:QM-0068130-01
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Product Details
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Description
GSK-3β inhibitor 13 (compound 47) is an orally active and potent GSK-3β inhibitor with blood-brain permeability. GSK-3β inhibitor 13 inhibits GSK-3β and GSK-3α with IC50s of 0.73 nM and 0.35 nM, respectively. GSK-3β inhibitor 13 significantly decreases the phosphorylation of tau (IC50=58 nM), which leads the formation of the neurofibrillary tangles associated with Alzheimer's disease[1].
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CAS Number
[2227316-74-5]
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Molecular Formula
C23H22N6O2
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Molecular Weight
414.46
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Smiles
O=C(C1=CC=NN2C1=NC(C3=CC=CC=C3)=C2)NC4=C(C=CN=C4)N5CCOC(C5)C
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Target
AAK1; GSK-3; Pim; PKC; Tau Protein
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Isoform
GSK-3α; GSK-3β; PIM1; PKCθ
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Purity
99.74
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Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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GSK-3β inhibitor 13 [CAS 2227316-74-5]
GSK-3β inhibitor 13 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.