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GSK-3 inhibitor 3 [CAS 2227279-84-5]

GSK-3 inhibitor 3 [CAS 2227279-84-5]

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QM-0151550-01

£382.91 GBP
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Product Details

  • Description

    GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3, with IC50s of 0.35 nM and 0.25 nM for GSK-3α and GSK-3β, respectively. GSK-3 inhibitor 3 lowers levels of tau protein phosphorylation at S396 in a triple-transgenic mouse Alzheimer’s disease model, with IC50 of 10 nM. GSK-3 inhibitor 3 can be used for neurological disease research[1].

  • CAS Number

    [2227279-84-5]

  • Molecular Formula

    C23H15FN6O

  • Molecular Weight

    410.4

  • Smiles

    FC1=CC=C(C2=C(C=NC=C2)NC(C3=CC=NC(NC4=CC=C(C#N)C=C4)=N3)=O)C=C1

  • Target

    CDK; GSK-3; Tau Protein

  • Isoform

    CDK2; CDK5; GSK-3α; GSK-3β

  • Purity

    98.72

  • Solubility

    DMSO : 50 mg/mL (ultrasonic)

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature
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Variant Variant total Quantity Price Variant total
5 mgQM-0151550-01
5 mgQM-0151550-01
£382.91/ea		 £0.00
£382.91/ea £0.00
10 mgQM-0151550-02
10 mgQM-0151550-02
£583.38/ea		 £0.00
£583.38/ea £0.00
25 mgQM-0151550-03
25 mgQM-0151550-03
£1,124.06/ea		 £0.00
£1,124.06/ea £0.00
50 mgQM-0151550-04
50 mgQM-0151550-04
£1,769.22/ea		 £0.00
£1,769.22/ea £0.00
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GSK-3 inhibitor 3 [CAS 2227279-84-5]

GSK-3 inhibitor 3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.