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GSK-3 inhibitor 4 [CAS 2227279-83-4]

GSK-3 inhibitor 4 [CAS 2227279-83-4]

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QM-0071427-01

£577.31 GBP
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Product Details

  • Description

    GSK-3 inhibitor 4 is an orally active and brain-penetrant inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3β), 0.45 nM (GSK-3α), 0.47 μM, and 0.68 μM, respectively. GSK-3 inhibitor 4 effectively reduces the phosphorylation level of Tau protein. GSK-3 inhibitor 4 can be used in Alzheimer's disease (AD) studies[1].

  • CAS Number

    [2227279-83-4]

  • Molecular Formula

    C22H15F2N5O

  • Molecular Weight

    403.38

  • Smiles

    O=C(C1=NC(NC2=CC=C(C=C2)F)=NC=C1)NC3=C(C4=CC=C(F)C=C4)C=CN=C3

  • Target

    CDK; GSK-3

  • Isoform

    CDK2; CDK5; GSK-3α; GSK-3β

  • Purity

    98.77

  • Solubility

    10 mM in DMSO

  • Storage Conditions

    -20°C, 3 years (Powder)

  • Shipping Conditions

    Blue Ice
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Variant Variant total Quantity Price Variant total
1 mgQM-0071427-01
1 mgQM-0071427-01
£577.31/ea		 £0.00
£577.31/ea £0.00
5 mgQM-0071427-02
5 mgQM-0071427-02
£1,618.57/ea		 £0.00
£1,618.57/ea £0.00
10 mgQM-0071427-03
10 mgQM-0071427-03
£2,246.72/ea		 £0.00
£2,246.72/ea £0.00
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GSK-3 inhibitor 4 [CAS 2227279-83-4]

GSK-3 inhibitor 4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.