H3R antagonist 8 [CAS 3097193-89-7]
H3R antagonist 8 [CAS 3097193-89-7]
SKU:QM-0014922
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Product Details
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Description
H3R antagonist 8 is a selective nonimidazole histamine H3 receptor antagonist (IC50 = 0.35 μM) . H3R antagonist 8 exhibits hERG channel blockade activity (IC50 = 0.67 μM) . H3R antagonist 8 inhibits seizures by antagonizing H3 receptor. H3R antagonist 8 reduces tonic hind limb extension (THLE) in mice in the maximal electroshock seizure (MES) model (ED50 = 20.21 mg/kg) and and shortens pentylenetetrazol (PTZ) -induced total movement distance in AB strain zebrafish larvae. H3R antagonist 8 can be used for the study of epilepsy[1].
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CAS Number
[3097193-89-7]
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Molecular Formula
C23H27ClN2O2
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Molecular Weight
398.93
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Smiles
CCN(CC)CCCOC1=CC=C(C2=C(C3=CC=CC=C3Cl)OC(C)=N2)C=C1
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Target
Histamine Receptor
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Isoform
H3 Receptor
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Shipping Conditions
Room temperature
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H3R antagonist 8 [CAS 3097193-89-7]
H3R antagonist 8 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.