HDAC6 ligand-7
HDAC6 ligand-7
SKU:QM-0015879
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Product Details
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Description
HDAC6 ligand-7 (Compound 16a) is a positron emission tomography (PET) tracer for the deacetylase 6 (HDAC6) enzyme with a Kd value of 1.66 nM. HDAC6 ligand-7 exhibits excellent HDAC6 inhibitory activity, with IC50 values of 2.7 and 3.7 nM for hHDAC6 and mHDAC6, respectively, and has high selectivity for HDAC1/4/7/8. HDAC6 ligand-7 after being radioactively labeled with fluorine-18, [¹⁸F]HDAC6 ligand-7 shows varying degrees of radioactive uptake in PET, which can reflect the specific binding to HDAC6. HDAC6 ligand-7 can be used for the study of HDAC6 imaging[1].
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Molecular Formula
C17H15FN4O2
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Molecular Weight
326.33
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Smiles
O=C(NO)C1=CC=C(CN2N=C(C)C=C2C3=NC(F)=CC=C3)C=C1
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Target
HDAC
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Isoform
HDAC1; HDAC4; HDAC6; HDAC7; HDAC8
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Shipping Conditions
Room temperature
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HDAC6 ligand-7
HDAC6 ligand-7 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.