1
/
of
1
Hdm2 E3 ligase inhibitor 1 [CAS 414905-09-2]
Hdm2 E3 ligase inhibitor 1 [CAS 414905-09-2]
SKU:QM-0086122
Price on request
Quantity
Request quote or documents
![Hdm2 E3 ligase inhibitor 1 [CAS 414905-09-2]](http://quantimol.com/cdn/shop/files/quantimol-021.png?v=1773515276&width=1445)
Product Details
-
Description
Hdm2 E3 ligase inhibitor 1 (Compound 1) is a reversible inhibitor for Hdm2 (an E3 ubiquitin ligase) -mediated ubiquitination of the p53 protein with an IC50 of 12.7 μM. Hdm2 E3 ligase inhibitor 1 binds Hdm2, blocks Hdm2-catalyzed ubiquitin transfer from preligated Ub-Ubc4 to p53, inhibits p53 ubiquitination, stabilizes p53 protein in tumor cell and exhibits antitumor efficacy[1].
-
CAS Number
[414905-09-2]
-
Molecular Formula
C10H8F6N2O3S
-
Molecular Weight
350.24
-
Smiles
O=C(NC1=CC=C(S(=O)(N)=O)C=C1)C(C(F)(F)F)C(F)(F)F
-
Target
E1/E2/E3 Enzyme; MDM-2/p53
-
Shipping Conditions
Room temperature
Related Products
- QM-0025230 β-catenin inhibitory peptoid [CAS 2579070-02-1]
- QM-0023369 α-Synuclein inhibitor 14 [CAS 408324-13-0]
- QM-0015918 β2AR agonist 5 [CAS 2759727-47-2]
- QM-0015098 α2AR agonist 2 [CAS 719277-27-7]
- QM-0013035 α-Synuclein inhibitor 15 [CAS 414880-30-1]
- QM-0013016 αMβ2 integrin agonist-1
- QM-0013015-01 α5β1 integrin agonist-2
- QM-0013014 α4β1 antagonist-1
- QM-0012730-01 YTHDF2 ligand-1 [CAS 3093182-34-1]
- QM-0009574 α5-GABAA receptor modulator 1
Other industry favorites
- QM-0025230 β-catenin inhibitory peptoid [CAS 2579070-02-1]
- QM-0023369 α-Synuclein inhibitor 14 [CAS 408324-13-0]
- QM-0141339-01 δ-Secretase inhibitor 11 [CAS 842964-18-5]
- QM-0196447-01 α2β1 Integrin Ligand Peptide (TFA)
- QM-0065091 μ opioid receptor agonist 1 [CAS 2667632-83-7]
- QM-0070729 β-Catenin modulator-5 [CAS 902168-07-4]
- QM-0150540-01 β-FXR antagonist 1 [CAS 2295804-92-9]
- QM-0153508-01 α-Synuclein inhibitor 11
- QM-0122210 δ opioid receptor antagonist 1
- QM-0121938 α-Synuclein inhibitor 13
Hdm2 E3 ligase inhibitor 1 [CAS 414905-09-2]
Hdm2 E3 ligase inhibitor 1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.