Hh Pathway-IN-1 [CAS 599150-20-6]
Hh Pathway-IN-1 [CAS 599150-20-6]
SKU:QM-0112587-01
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Product Details
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Description
Hh Pathway-IN-1, a Hedgehog (Hh) pathway inhibitor, is a potent Gli antagonist. Hh Pathway-IN-1 inhibits Hh pathway functional with an IC50 value of 1.1 µM in C3H10T1/2 cells. Hh Pathway-IN-1 does not inhibit Wnt signaling. Hh Pathway-IN-1 shows anti-proliferative activity. Hh Pathway-IN-1 decreases the GLI1 mRNA expression. Hh Pathway-IN-1 inhibits colony formation in a dose-dependent manner[1][2].
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CAS Number
[599150-20-6]
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Molecular Formula
C27H29NO6
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Molecular Weight
463.53
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Smiles
COCCOC(C1=C(C)NC(CC(C2=C(C=CC=C2)OC)CC3=O)=C3C1C4=CC(O)=CC=C4)=O
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Target
Gli; Hedgehog
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Purity
99.06
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H400
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Precautions
H302, H400
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Hh Pathway-IN-1 [CAS 599150-20-6]
Hh Pathway-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.