HsClpP activator-2
HsClpP activator-2
SKU:QM-0013400
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Product Details
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Description
HsClpP activator-2 is an orally active HsClpP agonist with a KD of 40 nM. HsClpP activator-2 potently inhibits SCLC cells including H69 (IC50 = 0.17 μM) and H82 (IC50 = 0.19 μM) . HsClpP activator-2 disrupts mitochondrial membrane potential (MMP), as well as induces apoptosis and ROS in H82 cells. HsClpP activator-2 significantly inhibits tumor growth in non-SMC xenograft models with a tumor growth inhibition. HsClpP activator-2 can be used for the study of small cell lung carcinoma (SCLC) [1].
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Molecular Formula
C29H26F3N3O2
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Molecular Weight
505.53
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Smiles
O=C(C1=C(C2=CC=C(CO)C=C2)CCN(CC3=CC=CC(C#N)=C3)C1)NCC4=CC=C(C(F)(F)F)C=C4
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Target
Apoptosis; ClpP; Reactive Oxygen Species (ROS)
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Shipping Conditions
Room temperature
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HsClpP activator-2
HsClpP activator-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.