HSD17B13/PPAR modulator-1
HSD17B13/PPAR modulator-1
SKU:QM-0015659
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Product Details
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Description
HSD17B13/PPAR modulator-1 (Compound 17) is a HSD17B13/PPAR multitarget modulator. HSD17B13/PPAR modulator-1 is an inhibitor of HSD17B13, with its IC50 value being 0.91 μM. HSD17B13/PPAR modulator-1 is a PPAR agonist, with the EC50 values for PPARα, PPARδ, and PPARγ being 1.55, 0.12, and 0.01 μM respectively. HSD17B13/PPAR modulator-1 can significantly improve liver function, regulate lipid metabolism, alleviate fibrosis, and exert antioxidant and anti-inflammatory effects in the model of metabolic dysfunction-related steatohepatitis (MASH) . HSD17B13/PPAR modulator-1 can be used for the study of MASH[1].
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Molecular Formula
C31H29F3N2O5S
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Molecular Weight
598.63
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Smiles
O=C(C1=C(C)N=C(S1)C2=CC(F)=C(F)C(O)=C2F)N(CC3=CC(C)=C(C(C)=C3)OC(C)(C(O)=O)C)CC4=CC=CC=C4
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Target
17β-HSD; PPAR
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Isoform
PPARα; PPARγ; PPARδ
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Shipping Conditions
Room temperature
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HSD17B13/PPAR modulator-1
HSD17B13/PPAR modulator-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.