IRAK4 modulator-2 [CAS 1356013-27-8]
IRAK4 modulator-2 [CAS 1356013-27-8]
SKU:QM-0014550-01
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Product Details
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Description
IRAK4 modulator-2 (Compound 5) is a selective dual Interleukin-1 Receptor Associated Kinase 4 (IRAK4) and IRAK1 inhibitor with IC50 values of 0.005 μM and 0.97 μM, erespectively. IRAK4 modulator-2 blocks IRAK-mediated signaling pathways (e.g., JAK-STAT, NF-κB pathways), reduces the production of pro-inflammatory cytokines (e.g., IL-1, TNF), and exerts anti-inflammatory activity. IRAK4 modulator-2 is promising for research of autoimmune diseases and inflammatory diseases, such as rheumatoid arthritis, psoriasis, inflammatory bowel disease[1].
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CAS Number
[1356013-27-8]
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Molecular Formula
C20H22ClN5O2
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Molecular Weight
399.87
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Smiles
O=C(C1=C2N=CC=CN2N=C1)NC3=CC(Cl)=CC=C3N4CCC(C(C)O)CC4
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Target
IRAK; JAK; NF-κB; STAT
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Isoform
IRAK1; IRAK4
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Purity
99.86
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Solubility
DMSO : 125 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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IRAK4 modulator-2 [CAS 1356013-27-8]
IRAK4 modulator-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.