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K-Ras ligand-Linker Conjugate 1 [CAS 2749492-84-8]

K-Ras ligand-Linker Conjugate 1 [CAS 2749492-84-8]

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QM-0061313

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Product Details

  • Description

    K-Ras ligand-Linker Conjugate 1 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 1 can be used in the synthesis of PROTAC K-Ras Degrader-1 , which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].

  • CAS Number

    [2749492-84-8]

  • Molecular Formula

    C43H54N8O9

  • Molecular Weight

    826.94

  • Smiles

    O=C(N1CCOCCOCCOCCO[C@@H]2C[C@@H](COC3=NC4=C(CCNC4)C(N5CCN(C(OCC6=CC=CC=C6)=O)[C@@H](CC#N)C5)=N3)N(C)C2)C7=C(C=CC=C7)C1=O

  • Target

    Target Protein Ligand-Linker Conjugates

  • Solubility

    10 mM in DMSO

  • Shipping Conditions

    Room temperature

  • Hazard Statement

    H302-H315-H319-H335

  • Precautions

    P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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K-Ras ligand-Linker Conjugate 1 [CAS 2749492-84-8]

K-Ras ligand-Linker Conjugate 1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.