K-Ras ligand-Linker Conjugate 2 [CAS 2741300-61-6]
K-Ras ligand-Linker Conjugate 2 [CAS 2741300-61-6]
SKU:QM-0061314
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Product Details
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Description
K-Ras ligand-Linker Conjugate 2 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 2 can be used in the synthesis of PROTAC K-Ras Degrader-1 , which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
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CAS Number
[2741300-61-6]
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Molecular Formula
C45H58N8O7
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Molecular Weight
822.99
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Smiles
NCCOCCOCCOCCO[C@H]1CN(C)[C@H](COC2=NC3=C(CCN(C4=CC=CC5=C4C=CC=C5)C3)C(N6CCN(C(OCC7=CC=CC=C7)=O)[C@@H](CC#N)C6)=N2)C1
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Target
Target Protein Ligand-Linker Conjugates
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H315-H319-H335
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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K-Ras ligand-Linker Conjugate 2 [CAS 2741300-61-6]
K-Ras ligand-Linker Conjugate 2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.