K-Ras ligand-Linker Conjugate 4 [CAS 2378261-83-5]
K-Ras ligand-Linker Conjugate 4 [CAS 2378261-83-5]
SKU:QM-0143416-01
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Product Details
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Description
K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 , which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
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CAS Number
[2378261-83-5]
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Molecular Formula
C35H51N7O8
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Molecular Weight
697.82
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Smiles
O=C(N1[C@@H](CC#N)CN(C2=C3C(CNCC3)=NC(OC[C@H]4N(C)C[C@H](OCCOCCOCCOCCO)C4)=N2)CC1)OCC5=CC=CC=C5
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Target
Target Protein Ligand-Linker Conjugates
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Concentration
10mM
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Purity
98.76
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Storage Conditions
-20°C (Powder, stored under nitrogen)
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Shipping Conditions
Blue Ice
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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K-Ras ligand-Linker Conjugate 4 [CAS 2378261-83-5]
K-Ras ligand-Linker Conjugate 4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.