K-Ras ligand-Linker Conjugate 5 [CAS 2378261-85-7]
K-Ras ligand-Linker Conjugate 5 [CAS 2378261-85-7]
SKU:QM-0143417-01
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Product Details
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Description
K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 , which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
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CAS Number
[2378261-85-7]
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Molecular Formula
C42H59N7O8
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Molecular Weight
789.96
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Smiles
O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCO)C6)=N2)CC1)OC(C)(C)C
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Target
Target Protein Ligand-Linker Conjugates
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Purity
99.79
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Solubility
DMSO : ≥ 100 mg/mL
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Storage Conditions
-20°C (Powder, stored under nitrogen)
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Shipping Conditions
Blue Ice
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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K-Ras ligand-Linker Conjugate 5 [CAS 2378261-85-7]
K-Ras ligand-Linker Conjugate 5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.