K-Ras ligand-Linker Conjugate 6 (formate)
K-Ras ligand-Linker Conjugate 6 (formate)
SKU:QM-0005692-01
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Product Details
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Description
K-Ras ligand-Linker Conjugate 6 formate incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 formate can be used in the synthesis of PROTAC K-Ras Degrader-1 , which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
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Molecular Formula
C43H62N8O9
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Molecular Weight
835
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Smiles
O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCN)C6)=N2)CC1)OC(C)(C)C.OC=O
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Target
Target Protein Ligand-Linker Conjugates
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Purity
98.93
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Blue Ice
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K-Ras ligand-Linker Conjugate 6 (formate)
K-Ras ligand-Linker Conjugate 6 (formate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.