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KRAS G12C inhibitor 48 [CAS 3033236-94-8]
KRAS G12C inhibitor 48 [CAS 3033236-94-8]
SKU:QM-0066558
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Product Details
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Description
KRAS G12C inhibitor 48 (compound 6e) is a potent KRAS G12C inhibitor with an IC50 of 639.91 nM. KRAS G12C inhibitor 48 (0-50 µM) shows anti-proliferative activity with IC50s of 0.796, 6.33, 16.14 µM for H358, H23, A549 cells, respectively[1].
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CAS Number
[3033236-94-8]
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Molecular Formula
C36H39ClN8O2
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Molecular Weight
651.2
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Smiles
N#C/C(C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C(Cl)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)CC1)=O)=C\C7CC7
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Target
Ras
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Isoform
K-Ras
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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KRAS G12C inhibitor 48 [CAS 3033236-94-8]
KRAS G12C inhibitor 48 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.