KRas G12R inhibitor 1
KRas G12R inhibitor 1
SKU:QM-0150560-01
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Product Details
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Description
KRas G12R inhibitor 1 is a covalent inhibitor targeting the common oncogenic mutant KRas G12R with selectivity for the mutant arginine. KRas G12R inhibitor 1 possesses an α, β-diketoamide and exploits strong nucleophilicity of the mutant cysteine and irreversibly binds in the Switch II region of KRas. KRas G12R inhibitor 1 can be researched for K-Ras (G12R) -driven cancer such as pancreatic ductal adenocarcinoma (PDAC) [1].
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Molecular Formula
C39H38ClF7N6O9
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Molecular Weight
903.2
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Smiles
CC(C(O)(O)C(N1[C@@H]2CC[C@H]1CN(C3=NC(OCC45CCCN4CCC5)=NC6=C3C=NC(C7=C8C(Cl)=CC=CC8=CC=C7)=C6F)C2)=O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O
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Target
Ras
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Purity
98.19
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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KRas G12R inhibitor 1
KRas G12R inhibitor 1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.