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KRAS inhibitor-16 [CAS 2230873-67-1]
KRAS inhibitor-16 [CAS 2230873-67-1]
SKU:QM-0066955
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Product Details
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Description
KRAS inhibitor-16 (compound 3-11) is a potent KRAS G12C inhibitor with an IC50 of 0.457 µM. KRAS inhibitor-16 shows p-ERK inhibition activities with IC50s of 3.06, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-16 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
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CAS Number
[2230873-67-1]
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Molecular Formula
C20H16Cl2FN3O2S
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Molecular Weight
452.33
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Smiles
C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(O)=CC=C4Cl)=C(C3=NS2)F)Cl)=O
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Target
Ras
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Isoform
K-Ras
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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KRAS inhibitor-16 [CAS 2230873-67-1]
KRAS inhibitor-16 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.