KRAS inhibitor-27 [CAS 3033690-83-1]
KRAS inhibitor-27 [CAS 3033690-83-1]
SKU:QM-0008096-01
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Product Details
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Description
KRAS inhibitor-27 (Compound 15h) is the inhibitor for KRAS. KRAS inhibitor-27 inhibits KRAS G12D/G12V mutated cells AsPC-1, SW620 and KRAS wildtype cell HT-29 with IC50 of 378, 0.6 and 3230 nM, respectively. KRAS inhibitor-27 inhibits ERK phosphorylation (IC50 in cell AsPC-1 and SW620 is 0.6 nM and 1 nM), reduces the expression of DUSP4, thereby inhibiting MAPK signaling pathway[1].
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CAS Number
[3033690-83-1]
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Molecular Formula
C31H28ClF3N6O3S
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Molecular Weight
657.11
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Smiles
F[C@@H]1C[C@]2(COC3=NC4=C5C(OC[C@@]6(COCCCN64)[H])=C(Cl)[C@]([C@](C=CC(F)=C7S8)=C7C(C#N)=C8N)=C(F)C5=N3)CCCN2C1
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Target
ERK; p38 MAPK; Ras
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Shipping Conditions
Room temperature
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KRAS inhibitor-27 [CAS 3033690-83-1]
KRAS inhibitor-27 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.