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KRAS ligand 4
KRAS ligand 4
SKU:QM-0080588
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Product Details
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Description
KRAS ligand 4 (compound 2) is a bifunctional molecular glue degrader based on SOS1. KRAS ligand 4 reduces downstream signaling markers pERK and pS6 and displays anti-additional activity in cells with multiple KRAS mutations[1].
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Molecular Formula
C24H28ClF3N6O3
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Molecular Weight
540.97
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Smiles
FC(F)(F)C1=CC([C@@H](C)NC2=NC(Cl)=NC3=C2CN(C(C4(OC)CCN(C(C)=O)CC4)=O)C3)=CC(N)=C1
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Target
Molecular Glues; Ras; SOS1
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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KRAS ligand 4
KRAS ligand 4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.