Kv7.2/Kv7.3 activator-3 [CAS 1361107-81-4]
Kv7.2/Kv7.3 activator-3 [CAS 1361107-81-4]
SKU:QM-0013064
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Product Details
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Description
Kv7.2/Kv7.3 activator-3 (GRT-X) is an orally active Kv7.2/Kv7.3 and TSPO activator. Kv7.2/Kv7.3 activator-3 activates Kv7.2/Kv7.3, Kv7.4, and Kv7.5 with EC50 values of 0.37, 2.06, and 0.75 μM, respectively, and binds to TSPO with Ki values of 0.07 μM (rat membrane) and 4.60 μM (human U-118 MG cells) . Kv7.2/Kv7.3 activator-3 prevents motor neuron degeneration in mice and humans conditioned by ALS/FTD astrocytes. Kv7.2/Kv7.3 activator-3 stimulates dorsal root ganglion axonal growth through TSPO and Kv7.2/3 activation. Kv7.2/Kv7.3 activator-3 has anti-epileptic effects in epileptic seizure models. Kv7.2/Kv7.3 activator-3 reduces pain hypersensitivity in patients with diabetic neuropathy, promotes neuronal survival and regeneration after cervical neuropathy in rats, and accelerates the recovery of normal function of sensory and motor neurons[1][2][3][4].
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CAS Number
[1361107-81-4]
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Molecular Formula
C22H20F4N2O3
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Molecular Weight
436.4
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Smiles
O=C(C1=C(C)C2=C(N(CCOC)C1=O)C=C(C(F)(F)F)C=C2)NCC3=CC=CC(F)=C3
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Target
Potassium Channel; TSPO
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Isoform
Voltage-gated potassium channel
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Shipping Conditions
Room temperature
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Kv7.2/Kv7.3 activator-3 [CAS 1361107-81-4]
Kv7.2/Kv7.3 activator-3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.