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LXRα agonist 1 [CAS 1790089-97-2]
LXRα agonist 1 [CAS 1790089-97-2]
SKU:QM-0011483
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Product Details
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Description
LXRα agonist 1 (Compound 40) is a selective LXRα agonist (EC50: 42 nM). LXRα agonist 1 also has a certain agonistic effect on LXRβ (EC50: 266 nM). LXRα agonist 1 promotes target gene transcription by stabilizing the ligand binding domain (LBD) of LXRα. LXRα agonist 1 exhibits potent antitumor effects in hepatocellular carcinoma cells when combined with the Raf inhibitor Sorafenib. LXRα agonist 1 can be used in the study of lipotoxic cancers[1].
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CAS Number
[1790089-97-2]
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Molecular Formula
C28H27N3O2
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Molecular Weight
437.53
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Smiles
O=C(C(C1=CC=CC=C1)=C2NC3=CC=C(N4CCCCC4)C=C3)N(CC5=CC=CC=C5)C2=O
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Target
LXR
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Shipping Conditions
Room temperature
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LXRα agonist 1 [CAS 1790089-97-2]
LXRα agonist 1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.